Table 2.
Laboratory characteristics according to the shape of the glucose curve
| Shape of the glucose curve | p-value | ||
|---|---|---|---|
| Monophasic | Biphasic | ||
| N | 97 | 24 | – |
| FPG – mmol/L | 5.38 ± 0.63 | 5.15 ± 0.44 | 0.044ab |
| 30minPG – mmol/L | 9.22 [8.19–10.53] | 7.83 [6.76–9.04] | 0.001ab |
| 1hPG – mmol/L | 9.83 [8.36–11.64] | 6.03 [5.33–8.71] | < 0.001ab |
| 90minPG – mmol/L | 9.16 ± 2.40 | 6.60 ± 1.87 | < 0.001ab |
| 2hPG – mmol/L | 8.11 [5.92–9.39] | 6.33 [5.07–8.49] | 0.028ab |
| Glucose AUC – mmol/L.h | 17.55 ± 3.49 | 13.79 ± 2.99 | < 0.001a |
| HbA1c - % | 5.81 ± 0.63 | 5.74 ± 0.51 | 0.630 |
| Fasting serum insulin – pmol/L | 66.18 [45.15–100.47] | 44.07 [32.10–67.65] | 0.016ab |
| 2-h serum insulin – pmol/L | 476.70 [284.07–1017.51] | 301.50 [148.98–470.16] | 0.012ab |
| Gutt index | 3.22 [2.43–4.12] | 3.95 [3.06–5.29] | 0.006ab |
| Insulinogenic index | 0.91 [0.53–1.48] | 1.48 [0.70–2.95] | 0.017ab |
| Disposition index | 2.99 [1.76–5.82] | 6.42 [3.16–11.55] | 0.002ab |
| C-Peptide – nmol/L | 0.76 [0.43–0.96] | 0.43 [0.38–0.70] | 0.027ab |
| Glucagon – ng/L | 332.50 [200.00–640.00] | 600.00 [220.00–780.00] | 0.115 |
| Total cholesterol – mmol/L | 5.41 ± 1.14 | 5.41 ± 1.10 | 0.990 |
| HDL cholesterol – mmol/L | 1.22 [1.01–1.37] | 1.53 [1.23–1.76] | < 0.001ab |
| Triglycerides – mmol/L | 1.54 [1.04–2.14] | 1.29 [0.80–1.67] | 0.106 |
| hs-CRP – nmol/L | 25.67 [11.90–67.83] | 25.71 [13.48–63.29] | 0.930 |
| Adiponectin – μg/mL | 11.93 [9.06–15.74] | 15.42 [11.24–21.20] | 0.018ab |
| PP – pg/mL | 194.20 [103.65–392.15] | 464.45 [204.90–808.15] | 0.049ab |
aAfter adjustment for waist circumference: 0.254 for FPG, 0.004 for 30minPG, < 0.001 for 1hPG, < 0.001 for 90minPG, 0.075 for 2hPG, < 0.001 for glucose AUC, 0.311 for fasting serum insulin, 0.050 for 2-h serum insulin, 0.024 for Gutt index, 0.011 for insulinogenic index, 0.012 for disposition index, 0.291 for C-peptide, 0.003 for HDL cholesterol, 0.094 for adiponectin and 0.096 for PP.
bAfter adjustment for glucose AUC: 0.273 for FPG, 0.583 for 30minPG, < 0.001 for 1hPG, 0.348 for 90minPG, 0.049 for 2hPG, 0.379 for fasting serum insulin, 0.436 for 2-h serum insulin, 0.767 for Gutt index, 0.464 for insulinogenic index, 0.819 for disposition index, 0.697 for C-peptide, 0.005 for HDL cholesterol, 0.420 for adiponectin and 0.205 for PP