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. 2018 Aug 16;10:80. doi: 10.1186/s13195-018-0407-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — CSF SNAP-25 and SNAP-25/Aβ42 in relation to brain structure and WMH. Hippocampal volume, ventricular volume, and WMH at baseline (a, e, i) and over time (b, f, j) as a function of baseline CSF SNAP-25 in different diagnostic groups. Hippocampal volume, ventricular volume, and WMH at baseline (c, g, k) and over time (d, h, l) as a function of baseline SNAP-25/Aβ42 in different diagnostic groups. Biomarker levels and ratios are standardized to z scores. Aβ amyloid-β, AD Alzheimer’s disease, CN cognitively normal, pMCI progressive mild cognitive impairment, sMCI stable mild cognitive impairment, SNAP-25 synaptosomal-associated protein 25, WMH white matter hyperintensity