Fig. 6.

Diagram representing axonal structural changes detected by UHF-MRI and histology in ALS mice. a High magnification of axial section from spinal cord white matter (WM) in YFP control and YFP, G93A-SOD1 mice. b Diagram showing a reduction in axonal area and increased axonal density in the ALS mice. c - Graph displaying the relative changes in the membrane content (decrease in MBP described in Gatto et al. 2018 [31]), and relative decrease in axonal compartment and increase in the extra-axonal compartment. Note that concurrent changes in axonal compartment and membranes occurs without changes in G-ratios. Scale bar = 10 μm. Abbreviations: YFP, yellow fluorescent Protein; WM, white matter; GM: grey matter, MBP: myelin basic protein. AD: axial diffusion, RD: radial diffusion. G-ratio: ratio of the inner axonal diameter to the total outer diameter