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. 2018 Aug 16;14:12. doi: 10.1186/s13005-018-0169-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effects of curcumin on OPG/sRANKL ratio in culture supernatants of rat gingival fibroblasts. LPS downregulated OPG release from gingival fibroblasts; Curcumin reduced the downregulation (a). The sRANKL level in the culture supernatant of the LPS-treated cells was significantly higher than that of the control cells. LPS upregulated sRANKL release from gingival fibroblasts; curcumin reduced this upregulation (b). The OPG/sRANKL ratio decreased significantly in the LPS group. Curcumin inhibited the LPS-induced decrease in the OPG/sRANKL ratio (c). *Different from Control group (P < 0.05). # Different from LPS group (P < 0.05). & Different from LPS+ Curcumin (10 μM) group (P < 0.05)