Fig. 3.

Structure of the Tie2–Ang2-BD_BC5–α_vβ₃ complex. The Tie2 structure was aligned into the last frame of the Ang2-BD_BC5–integrin α_vβ₃ MD simulation. Tie2 is shown in cyan, Ang2-BD_BC5 in beige, α_v in yellow, and β₃ in green. Tie2-binding residues of Ang2 are colored magenta and NTCRGDCLP mutant residues in red. A zoom-in of the binding interface between Ang2-BD_BC5 and α_vβ₃ integrin is also shown. On the right, an all-atom representation of the mutant residues of Ang2-BD_BC5 is shown in stick form