Table 1.

Meta-analysis between the MTHFR rs1801133 polymorphism and CAD risk

Model	Group or subgroup	OR	95% CI	P heterogeneity	P OR
Allelic model (T vs C)	Total	1.11	1.06–1.17	< 0.01	< 0.01
	Studies in HWE	1.11	1.06–1.16	< 0.01	< 0.01
	Male	1.04	0.90–1.20	< 0.01	0.59
	Female	0.98	0.88–1.08	0.40	0.63
	Caucasian	1.03	0.99–1.07	< 0.01	0.10
	Asian	1.24	1.11–1.39	< 0.01	< 0.01
	African	1.30	0.84–2.00	< 0.01	0.24
	Other ethnicity	1.30	0.96–1.76	< 0.01	0.09
Additive model (TT vs CC)	Total	1.25	1.14–1.37	< 0.01	< 0.01
	Studies in HWE	1.23	1.12–1.35	< 0.01	< 0.01
	Male	1.22	0.96–1.55	< 0.01	0.10
	Female	0.93	0.75–1.16	0.65	0.53
	Caucasian	1.08	1.00–1.17	0.03	0.05
	Asian	1.46	1.20–1.76	< 0.01	< 0.01
	African	1.96	0.84–4.60	< 0.01	0.12
	Other ethnicity	1.83	0.93–3.59	< 0.01	0.08
Dominant model (TT + CT vs CC)	Total	1.11	1.04–1.17	< 0.01	< 0.01
	Studies in HWE	1.11	1.05–1.17	< 0.01	< 0.01
	Male	1.00	0.80–1.25	< 0.01	0.98
	Female	0.98	0.83–1.16	0.20	0.84
	Caucasian	1.02	0.97–1.06	0.05	0.45
	Asian	1.27	1.08–1.50	< 0.01	< 0.01
	African	1.22	0.78–1.92	< 0.01	0.39
	Other ethnicity	1.30	0.95–1.77	< 0.01	0.10
Recessive model (TT vs CT + CC)	Total	1.22	1.12–1.32	< 0.01	< 0.01
	Studies in HWE	1.20	1.11–1.30	< 0.01	< 0.01
	Female	0.96	0.78–1.17	0.76	0.67
	Male	1.21	0.96–1.51	< 0.01	0.10
	Caucasian	1.09	1.01–1.17	0.06	0.02
	Asian	1.36	1.14–1.62	< 0.01	< 0.01
	African	1.90	0.84–4.30	< 0.01	0.13
	Other ethnicity	1.71	0.94–3.12	< 0.01	0.08

MTHFR 5,10-methylenetetrahydrofolate reductase gene, CAD coronary artery disease, OR odds ratio, 95% CI 95% confidence interval, HWE Hardy-Weinberg equilibrium