Table 2.
Meta-analysis between the MTHFR rs1801133 polymorphism and plasma lipid levels
| Group or subgroup | Comparison (Subjects) | SMD (95% CI) | P Heterogeneity | P SMD |
|---|---|---|---|---|
| TG | ||||
| All | 62 (39,760) | 0.03 (−0.01–0.06) | < 0.01 | 0.11 |
| Studies in HWE | 46 (34,889) | 0.01 (− 0.01–0.03) | 0.11 | 0.44 |
| Male | 4 (2518) | 0.00 (− 0.08–0.08) | 0.71 | 0.96 |
| Female | 8 (1589) | 0.13 (− 0.07–0.33) | 0.01 | 0.21 |
| Caucasian | 25 (29,136) | 0.00 (−0.04–0.04) | 0.11 | 0.93 |
| Asian | 24 (8639) | 0.05 (−0.02–0.13) | < 0.01 | 0.16 |
| African | 2 (191) | 0.20 (−0.09–0.48) | 0.65 | 0.18 |
| Other ethnicity | 11 (1794) | 0.07 (−0.03–0.17) | 0.79 | 0.15 |
| CAD | 10 (2907) | 0.01 (−0.06–0.09) | 0.54 | 0.74 |
| T2DM | 6 (812) | 0.07 (−0.14–0.28) | 0.09 | 0.51 |
| Hypertension | 4 (1522) | 0.03 (−0.09–0.15) | 0.70 | 0.63 |
| Healthy or control | 17 (26,612) | 0.01 (−0.02–0.04) | 0.33 | 0.50 |
| TC | ||||
| All | 79 (72,848) | 0.04 (0.01–0.07) | < 0.01 | 0.02 |
| Studies in HWE | 57 (51,283) | 0.01 (−0.00–0.03) | 0.13 | 0.12 |
| Male | 11 (5067) | 0.03 (−0.05–0.11) | 0.18 | 0.52 |
| Female | 15 (28,790) | 0.11 (0.02–0.19) | 0.01 | 0.02 |
| Caucasian | 26 (41,744) | 0.00 (−0.05–0.04) | 0.02 | 0.95 |
| Asian | 36 (13,385) | 0.10 (0.04–0.15) | 0.01 | < 0.01 |
| African | 3 (277) | −0.32 (−1.24–0.60) | < 0.01 | 0.49 |
| Other ethnicity | 14 (17,442) | −0.01 (− 0.04–0.02) | 0.48 | 0.55 |
| CAD | 9 (2676) | 0.02 (−0.06–0.10) | 0.45 | 0.66 |
| T2DM | 5 (705) | 0.03 (−0.20–0.27) | 0.09 | 0.77 |
| Hypertension | 6 (11,288) | −0.02 (− 0.06–0.02) | 0.47 | 0.34 |
| Healthy or control | 31 (49,859) | 0.07 (0.02–0.12) | < 0.01 | < 0.01 |
| LDL-C | ||||
| All | 65 (29,424) | 0.07 (0.01–0.12) | < 0.01 | 0.01 |
| Studies in HWE | 45 (13,946) | 0.04 (0.01–0.08) | 0.14 | 0.03 |
| Male | 10 (4999) | 0.04 (−0.04–0.12) | 0.13 | 0.36 |
| Female | 13 (3662) | 0.09 (0.01–0.16) | 0.43 | 0.02 |
| Caucasian | 18 (6226) | 0.00 (−0.05–0.05) | 0.71 | 0.95 |
| Asian | 31 (11,417) | 0.10 (0.05–0.15) | 0.10 | < 0.01 |
| African | 3 (277) | 1.16 (−0.94–3.25) | < 0.01 | 0.28 |
| Other ethnicity | 13 (11,504) | −0.02 (− 0.10–0.06) | 0.23 | 0.67 |
| CAD | 9 (2807) | 0.00 (−0.08–0.07) | 0.77 | 0.92 |
| T2DM | 6 (799) | 0.01 (−0.25–0.26) | 0.02 | 0.96 |
| Hypertension | 5 (10,843) | 0.06 (−0.05–0.18) | 0.12 | 0.30 |
| Healthy or control | 25 (8989) | 0.07 (0.01–0.13) | 0.02 | 0.02 |
| HDL-C | ||||
| All | 76 (76,811) | −0.02 (− 0.05–0.02) | < 0.01 | 0.30 |
| Studies in HWE | 57 (61,438) | −0.02 (− 0.03--0.00) | 0.72 | 0.04 |
| Male | 10 (3467) | −0.04 (− 0.11–0.03) | 0.79 | 0.29 |
| Female | 14 (28,630) | −0.05 (− 0.12–0.02) | 0.10 | 0.19 |
| Caucasian | 25 (51,768) | −0.03 (− 0.07–0.01) | 0.02 | 0.16 |
| Asian | 25 (9553) | 0.00 (−0.06–0.06) | < 0.01 | 0.92 |
| African | 2 (186) | 0.15 (− 0.14–0.43) | 0.99 | 0.32 |
| Other ethnicity | 3 (282) | −0.10 (− 0.18--0.02) | 0.26 | 0.01 |
| CAD | 8 (2570) | 0.05 (− 0.04–0.13) | 0.65 | 0.27 |
| T2DM | 6 (799) | 0.01 (−0.14–0.16) | 0.88 | 0.89 |
| Hypertension | 4 (1522) | −0.03 (− 0.15–0.08) | 0.85 | 0.56 |
| Healthy or control | 32 (56,554) | 0.00 (− 0.05–0.04) | < 0.01 | 0.97 |
MTHFR 5,10-methylenetetrahydrofolate reductase gene, SMD standardized mean difference, 95% CI 95% confidence interval, HWE Hardy-Weinberg equilibrium, TG triglyceride, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, CAD coronary artery disease, T2DM type 2 diabetes mellitus