Table 4.
Meta-analysis between the MTHFR rs1801133 polymorphism and plasma lipid levels after excluding the comparisons with heterogeneity
| Group or subgroup | Comparison (Subjects) |
SMD (95% CI) | P Heterogeneity | P SMD |
|---|---|---|---|---|
| TG | ||||
| All | 59 (39,196) | 0.01 (−0.01–0.03) | 0.32 | 0.22 |
| Male | 4 (2518) | 0.00 (− 0.08–0.08) | 0.71 | 0.96 |
| Female | 7 (1429) | 0.02 (− 0.09–0.13) | 0.06 | 0.74 |
| Caucasian | 24 (28,976) | 0.01 (− 0.02–0.03) | 0.31 | 0.54 |
| Asian | 22 (8235) | 0.02 (−0.03–0.06) | 0.17 | 0.50 |
| African | 2 (191) | 0.20 (−0.09–0.48) | 0.65 | 0.18 |
| Other ethnic | 11 (1794) | 0.07 (−0.03–0.17) | 0.79 | 0.15 |
| CAD | 10 (2907) | 0.01 (−0.06–0.09) | 0.54 | 0.74 |
| T2DM | 6 (812) | 0.07 (−0.08–0.22) | 0.09 | 0.35 |
| Hypertension | 4 (1522) | 0.03 (−0.09–0.15) | 0.70 | 0.63 |
| Healthy or control | 17 (26,612) | 0.01 (−0.01–0.04) | 0.33 | 0.28 |
| TC | ||||
| All | 70 (70,024) | 0.01 (−0.00–0.03) | 0.38 | 0.15 |
| Male | 11 (5067) | 0.02 (−0.04–0.08) | 0.18 | 0.44 |
| Female | 11 (28, 074) | 0.02 (−0.00–0.04) | 0.54 | 0.09 |
| Caucasian | 22 (41,176) | 0.01 (−0.01–0.03) | 0.81 | 0.42 |
| Asian | 32 (11,220) | 0.06 (0.02–0.10) | 0.34 | < 0.01 |
| African | 2 (186) | 0.15 (−0.14–0.44) | 0.15 | 0.31 |
| Other ethnic | 14 (17,442) | −0.01 (− 0.04–0.02) | 0.48 | 0.55 |
| CAD | 10 (2907) | 0.02 (−0.06–0.10) | 0.45 | 0.66 |
| T2DM | 5 (705) | 0.07 (−0.09–0.23) | 0.09 | 0.38 |
| Hypertension | 6 (11,288) | −0.02 (− 0.06–0.02) | 0.47 | 0.34 |
| Healthy or control | 26 (47,611) | 0.02 (−0.00–0.04) | 0.36 | 0.08 |
| LDL-C | ||||
| All | 62 (18,739) | 0.04 (0.01–0.07) | 0.10 | 0.01 |
| Male | 10 (4999) | 0.04 (−0.02–0.10) | 0.13 | 0.24 |
| Female | 13 (3662) | 0.09 (0.01–0.16) | 0.43 | 0.02 |
| Caucasian | 18 (6226) | 0.00 (−0.05–0.05) | 0.71 | 0.95 |
| Asian | 30 (10,439) | 0.08 (0.04–0.12) | 0.16 | < 0.01 |
| African | 2 (186) | −0.17 (−0.46–0.12) | 0.14 | 0.25 |
| Other ethnic | 12 (1888) | 0.00 (−0.10–0.09) | 0.19 | 0.98 |
| CAD | 9 (2807) | 0.00 (−0.08–0.07) | 0.77 | 0.92 |
| T2DM | 6 (799) | 0.06 (−0.09–0.21) | 0.02 | 0.43 |
| Hypertension | 4 (1227) | 0.14 (0.01–0.27) | 0.87 | 0.03 |
| Healthy or control | 24 (8011) | 0.06 (0.01–0.11) | 0.06 | 0.01 |
| HDL-C | ||||
| All | 70 (65,091) | −0.02 (−0.03--0.00) | 0.48 | 0.05 |
| Male | 10 (3467) | −0.04 (− 0.11–0.03) | 0.79 | 0.29 |
| Female | 14 (28,630) | −0.01 (− 0.03–0.02) | 0.10 | 0.61 |
| Caucasian | 23 (51,561) | −0.02 (− 0.03–0.00) | 0.49 | 0.08 |
| Asian | 33 (11,456) | −0.02 (− 0.06–0.02) | 0.22 | 0.42 |
| African | 2 (186) | 0.15 (−0.14–0.43) | 0.99 | 0.32 |
| Other ethnic | 12 (1888) | −0.04 (− 0.13–0.05) | 0.70 | 0.41 |
| CAD | 9 (2766) | 0.03 (−0.06–0.11) | 0.99 | 0.54 |
| T2DM | 6 (799) | 0.01 (−0.14–0.16) | 0.88 | 0.89 |
| Hypertension | 4 (1522) | −0.03 (− 0.15–0.08) | 0.85 | 0.56 |
| Healthy or control | 30 (54,825) | −0.02 (− 0.03–0.00) | 0.05 | 0.06 |
MTHFR 5,10-methylenetetrahydrofolate reductase gene, SMD standardized mean difference, 95% CI 95% confidence interval, TG triglyceride, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, CAD coronary artery disease, T2DM type 2 diabetes mellitus