Fig. 4.

KPNA2 was associated with the metabolic reprogramming in the glioma xenografts. The U87 cells transfected with small hairpin RNAs of KPNA2 or scrambled nonspecific shRNAs were implanted into the right frontal lobes of the immunocompromised mice. a Representative H&E staining images of mouse brains at 42 days after inoculation were shown. Asterisk indicates tumor (scale bar, 1 mm) b The estimated tumor volumes at that time. Data were presented as the mean ± s.d. from three independent experiments. **P < 0.05. c Curve graph indicated survival time of the xenografted mice. P < 0.05 is considered statistically significant. d The relative expressions and e the activities of key enzymes involved in the glycolytic metabolism of the xenograft tumors were determined. Data were presented as the mean ± s.d. from three independent experiments.*P < 0.05, **P < 0.01