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. 2018 Aug 14;11(5):1259–1270. doi: 10.1016/j.tranon.2018.07.015

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Proposed model of how Id2 and Notch3 attenuate EMT in breast cancer. (A) the E2A-E2A homodimerization with the co-repressors (CoR) binds to E-box sequences of Notch3 promoter and inactivates Notch3 transcription, permitting the repression of E-cadherin and up-regulation of vimentin to ultimately induce EMT in breast cancer. (B) the Id2-E2A heterodimerization E2A complex releases the binding with E-box of Notch3 promoter and activates Notch3 transcription, permitting the repression of vimentin and up-regulation of E-cadherin to attenuate EMT in breast cancer.