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. 2018 Jul 27;14(10):1256–1267. doi: 10.7150/ijbs.27100

Figure 3.

Figure 3

Knockdown of TIMMDC1 decreased gastric cancer cell migration, invasion and metastasis in vitro and in vivo. Scratch test (A,B) and transwell migration assay (C) were used to explore the effect of TIMMDC1 on the migration activity of SGC-7901 and BGC-823 cells. Results were expressed as mean ± SD. n = 3. *P < 0.05, **P < 0.01 vs. control group. Transwell invasion assay was used to investigate whether TIMMDC1 can also influence the invasion capacity of SGC-7901 and BGC-823 cells. Results were expressed as mean ± SD. n = 3. **P < 0.01 vs. control group. The representative images of pulmonary metastasis in the nude mice (E). HE tests showed that knockdown of TIMMDC1 significantly inhibit the metastases in the lung of nude mice (F).