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. 2018 Jul 13;14(10):1221–1231. doi: 10.7150/ijbs.25488

Figure 5.

Figure 5

MLN0128 and AZD1775 is effective in repression of SCLC xenograft tumors. A. Mice bearing H69 or H82 xenograft tumors were treated with vehicle, MLN0128 (1mg/kg/day), or AZD1775 (40mg/kg every other day), or MLN0128 + AZD1775 combination therapy by oral gavage. Data are presented as the mean volume ± SEM. B. Tumor growth inhibition (TGI) was greater in MLN0128-treated mice than AZD1775-treated mice, and particularly pronounced in mice receiving AZD1775 + MLN0128 combination therapy. C. Tissue lysates were prepared from H69 xenograft tumors and were analyzed by western blot using the indicated antibodies. β-actin was used as loading control. D. Tissue lysates were prepared from H82 xenograft tumors and were analyzed by western blot using the indicated antibodies. β-actin was used as loading control.