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. 2018 Jul 13;14(10):1245–1255. doi: 10.7150/ijbs.24347

FIGURE 4.

FIGURE 4

Caspase-1 inhibitor decreases the activation levels of caspase-1, IL-1β and IL-18. HEECs were treated with siNC, 1% ethanol+siNC, 1% ethanol+caspase-1 inhibitor or 1% ethanol+caspase-1 siRNA. A. The caspase-1 activation level was detected by immunofluorescence assay. B. Cell death was detected by TUNEL. The mRNA expression (C) and protein levels in different forms (D) of caspase-1, IL-1β and IL-18 were detected by real-time PCR and western blotting. The data are representative of five independent experiments and represent the means ± SD. **, p<0.01; ***, p<0.001; #, p<0.05; ##, p<0.01; ###, p<0.001.