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Classification of neutrophil elastase inhibitors.
| Classification | Origin | Examples |
|---|---|---|
| 1st generation | Biological | AAT (Aralast), Elafin (Tiprelestat) |
| 2sd generation | SMOLs, suicide inhibitors | ONO-5046 (Sivelestat), ONO-6818 (Freselestat) |
| 3rd generation | Modern, non-mechanism-based SMOLs | AZD9668 (Alvestat)* |
| 4th generation | Modern, non-mechanism-based SMOLs | BAY-678* |
| 5th generation | Pre-adaptive pharmacophores derived from 4th generation | BAY 85-8501* |
(*) Under clinical trials (Phase II).
