Table 2.
Univariate and multivariate analysis of prognosis factors for overall survival of hepatic resected patients with iCCA
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | p value | HR | 95%CI | p value | |
| Age (<60 vs. ≥60) | 1.226 | 0.767-1.961 | 0.394 | - | - | - |
| Gender (Male vs. Female) | 1.564 | 0.957-2.554 | 0.074 | - | - | - |
| HBV infection (Absent vs. Present) | 0.674 | 0.411-1.106 | 0.118 | - | - | - |
| Preoperative AFP (μg/l) (<9 vs. ≥9) | 0.814 | 0.469-1.414 | 0.466 | - | - | - |
| Preoperative CA19-9 (U/ml) (<35 vs. ≥35) | 1.647 | 0.952-2.849 | 0.075 | - | - | - |
| Tumor size (mm) (<50 vs. ≥50) | 2.183 | 1.312-3.631 | 0.003 | 2.170 | 1.287-3.661 | 0.004 |
| Vascular invasion (Absent vs. Present) | 1.622 | 0.976-2.695 | 0.062 | - | - | - |
| Lymph node metastasis (Absent vs. Present) | 3.161 | 1.916-5.215 | <0.001 | 2.587 | 1.552-4.311 | <0.001 |
| Tumor number (Single vs. Multiple) | 1.468 | 0.815-2.646 | 0.201 | - | - | - |
| Histologic differentiation (Well/Moderate vs. Poor) | 1.149 | 0.719-1.838 | 0.561 | - | - | - |
| Perineural sheath infiltration (Absent vs. Present) | 1.188 | 0.608-2.321 | 0.615 | - | - | - |
| Distribution (Unilobar vs. Bilobar) | 1.482 | 0.894-2.457 | 0.127 | - | - | - |
| Percentage of VEGFR-3 staining (<10% vs. 10-50% vs. >50%) |
1.322 | 0.938-1.864 | 0.111 | |||
| Intensity of VEGFR-3 staining (negative vs. moderate vs. strong) |
1.364 | 0.949-1.961 | 0.094 | |||
| VEGFR-3 expression (Negative vs. Positive) | 3.099 | 1.640-5.854 | <0.001 | 2.775 | 1.445-5.330 | 0.002 |