Table 3.
Univariate and multivariate analysis of prognosis factors for recurrence-free survival of hepatic resected patients with iCCA
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | p value | HR | 95%CI | p value | |
| Age (<60 vs. ≥60) | 1.302 | 0.827-2.049 | 0.254 | - | - | - |
| Gender (Male vs. Female) | 1.129 | 0.711-1.793 | 0.608 | - | - | - |
| HBV infection (Absent vs. Present) | 0.520 | 0.319-0.847 | 0.009 | 0.505 | 0.299-0.852 | 0.011 |
| Preoperative AFP (μg/l) (<9 vs. ≥9) | 0.889 | 0.527-1.499 | 0.658 | - | - | - |
| Preoperative CA19-9 (U/ml) (<35 vs. ≥35) | 1.499 | 0.897-2.504 | 0.122 | - | - | - |
| Tumor size (mm) (<50 vs. ≥50) | 2.044 | 1.258-3.321 | 0.004 | 2.366 | 1.396-4.009 | 0.001 |
| Vascular invasion (Absent vs. Present) | 1.286 | 0.782-2.116 | 0.322 | - | - | - |
| Lymph node metastasis (Absent vs. Present) | 2.816 | 1.747-4.538 | <0.001 | 1.985 | 1.181-3.336 | 0.010 |
| Tumor number (Single vs. Multiple) | 1.752 | 1.002-3.064 | 0.049 | 0.871 | 0.477-1.593 | 0.655 |
| Histologic differentiation (Well/Moderate vs. Poor) | 1.084 | 0.689-1.706 | 0.727 | - | - | - |
| Perineural sheath infiltration (Absent vs. Present) | 1.017 | 0.522-1.980 | 0.960 | - | - | - |
| Distribution (Unilobar vs. Bilobar) | 1.402 | 0.867-2.269 | 0.169 | - | - | - |
| Percentage of VEGFR-3 staining (<10% vs. 10-50% vs. >50%) |
1.348 | 0.959-1.894 | 0.086 | |||
| Intensity of VEGFR-3 staining (negative vs. moderate vs. strong) |
1.259 | 0.887-1.787 | 0.198 | |||
| VEGFR-3 expression (Negative vs. Positive) | 2.717 | 1.480-4.990 | 0.001 | 2.450 | 1.293-4.640 | 0.006 |