Table 3.
Incidence, Outcomes, and Prophylaxis for IFD According to Time Period
| Transplant Type | Transplantation in 2000–2006 (Jan 1, 2000–Dec 31, 2006) |
Transplantation in 2007–2013 (Jan 1, 2007–Dec 31, 2013) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Rate of IFD Events per Patient (n/N [%]) | IFD Events per 100000 Patient-Days | IFD Case- Fatality Rate (n/N [%]) | All-Cause Mortality Rate (n/N [%]) | Rate of Any Antifungal Prophylaxis (%); Rate of Mold-Specific Prophylaxis (%)a | Rate of IFD Events per Patient (n/N [%]) | IFD Events Per 100000 Patient-Days | IFD Case- Fatality Rate (n/N [%]) | All-Cause Mortality Rate (n/N [%]) | Rate of Any Antifungal Prophylaxis (%); Rate of Mold-Specific Prophylaxis (%)a | |
| All SOTs | 12/292 (4) | 25.5 | 3/12 (25) |
15/292 (5) |
7; 2 | 2/292 (1) | 3.9 | 0 | 8/292 (3) |
11; 4 |
| Heart/lung | 1/4 (25) |
229.9 | 1/1 (100) |
2/4 (50) |
25; 0 | 0/4 (0) | 0 | 0 | 2/4 (50) |
25; 25 |
| Lung | 4/18 (22) |
147.2 | 2/4 (50) |
3/18 (16) |
28; 22b | 1/17 (6) | 32.7 | 0 | 0 (0) | 47; 47c |
| Liver | 7/63 (11) |
68.5 | 0 (0) | 0/63 | 17; 2d | 1/109 (1) | 5.3 | 0 | 4/109 (4) |
16; 1 |
| Kidney | 0/132 (0) |
0 | 0 (0) | 0/132 | 0; 0e | 0/102 (0) | 0 | 0 | 0 (0) | 2; 0 |
| Heart | 0/75 (0) |
0 | 0 (0) | 12/75 (16) | 3; 1d | 0/60 (0) | 0 | 0 | 2/60 (3) |
8; 3d |
Abbreviations: IFD, invasive fungal disease; SOT, solid organ transplant.
aPatients who received antifungal prophylaxis in the first 5 days after transplant.
bThree patients received secondary prophylaxis.
cFive patients received secondary prophylaxis.
dOne patient received secondary prophylaxis.
eThree patients were excluded because of missing medication-administration records for first 5 days after transplant.