Table 1.
Characteristics of Included Studies
| Study (year) | Study Design | Country | No. of Neonates With Confirmed Chlamydial Conjunctivitis | Primary Outcome(s) Measured |
Follow-Up Time(s) | No. Lost to Follow-Up | Intervention(s) |
|---|---|---|---|---|---|---|---|
| Hammerschlag et al [4] (1982) | NRS | USA | 12 | Clinical cure, microbiological cure, complications, compliance | 2 and 6 wk, 3 and 6 mo, and 1 year | 1 | Erythromycin 50 mg/kg per day × 14 days |
| Patamasucon et al [25] (1982) | RCTa | USA | 41 | Clinical cure, microbiological cure, adverse effects, compliance | 1, 3, 7, 10, 14, 21, and 28 days | 12 | Erythromycin 20, 30, or 40 mg/kg × 21 days |
| Heggie et al [26] (1985) | RCTa | USA | 37 | Clinical cure, microbiological cure, adverse effects | 14 days and 4–6 wk | 8 | Erythromycin 50 mg/kg per day × 14 days |
| Fransen et al [27] (1986) | NRS | Kenya | 22 | Clinical cure, microbiological cure, adverse effects | 7–10 and 30 days | 5 | Erythromycin 50 mg/kg per day × 10 days |
| Sandström [28] (1987) | NRS | Sweden | 19 | Adverse effects | 0, 3, 4, 10, 18, and 32 days | NR | Erythromycin 50 mg/kg per day × 14 days |
| Sandström et al [29] (1988) | NRS | Sweden | 33 | Clinical cure, microbiological cure, complications, compliance | 1, 3, 4, 10, 14, 18, and 32 days and 2, 3, 4, 6, and 12 mo | 9 | Erythromycin 50 mg/kg per day × 14 days |
| Stenberg et al [30] (1990) | NRS | Sweden | 45 | Clinical cure, microbiological cure, complications, adverse effects | 1 mo and 1 year | 16 | Erythromycin 40–50 mg/kg per day × 14 days |
| Stenberg et al [31] (1991) | RCTa | Sweden | 14 | Clinical cure, microbiological cure, complications, adverse effects | 1 mo | NR | Erythromycin 200 mg/day × 10 days |
| Yescas-Buendía et al [32] (1993) | NRS | Mexico | 32 | Clinical cure, complications | 5 and 6 days and 3 and 6 mo | 0 | Erythromycin 30–40 mg/kg per day × 14 days (intravenously or orally)b |
| Hammerschlag [33] (1998) | NRS | USA | 13 | Clinical cure, microbiological cure, adverse effects | 1–6 wk | 1 | Azithromycin 20 mg/kg single dose or × 3 days; erythromycin 50 mg/kg per day × 14 days |
| Chang et al [34] (2006) | NRS | Hong Kong | 19 | Clinical cure, complications, adverse effects | 2 wk and 6 mo | NR | Erythromycin 50 mg/kg per day × 14 days |
| Yip et al [15] (2007) | NRS | Hong Kong | 24 | Microbiological cure, complications | 3 wk and 3 mo | 4 | Erythromycin 50 mg/kg per day × 14 days |
Abbreviations: NR, not reported; RCT, randomized controlled trial; NRS, nonrandomized study.
aOnly 1 treatment arm in which neonates received erythromycin was used in the analysis. The other treatment arm provided neonates with a treatment not covered in this review.
bIntravenous erythromycin was administered to 16 of 32 neonates with concomitant chlamydial pneumonia.