Table 1.
Demographics and Baseline Characteristics of the ACTIVExtend Population at Baseline of ACTIVE and at the Baseline of ACTIVExtend (Cumulative Mo 19)
|
|
At ACTIVE Baseline
|
At ACTIVExtend Baseline
|
||
|---|---|---|---|---|
| Characteristic | PBO/ALN (n = 581) | ABL/ALN (n = 558) | PBO/ALN (n = 581) | ABL/ALN (n = 558) |
| Age | ||||
| Mean, y (SD) | 68.5 (6.3) | 68.6 (6.5) | 70.1 (6.29) | 70.2 (6.54) |
| <65, n (%) | 114 (19.6) | 106 (19.0) | 86 (14.8) | 93 (16.7) |
| 65 to < 75, n (%) | 370 (63.7) | 351 (62.9) | 359 (61.8) | 327 (58.6) |
| ≥75, n (%) | 97 (16.7) | 101 (18.1) | 136 (23.4) | 138 (24.7) |
| Race/ethnicity, n (%) | ||||
| White | 447 (76.9) | 433 (77.6) | 447 (76.9) | 433 (77.6) |
| Asian | 106 (18.2) | 101 (18.1) | 106 (18.2) | 101 (18.1) |
| Black or African American | 18 (3.1) | 19 (3.4) | 18 (3.1) | 19 (3.4) |
| Other | 10 (1.7) | 5 (0.9) | 10 (1.7) | 5 (0.9) |
| Hispanic or Latino | 139 (23.9) | 124 (22.2) | 139 (23.9) | 124 (22.2) |
| Mean years since menopause (SD) | 19.8 (7.9) | 20.4 (8.2) | 21.3 (7.94) | 21.9 (8.23) |
| Region, n (%) | ||||
| North America | 7 (1.2) | 9 (1.6) | 7 (1.2) | 9 (1.6) |
| South America | 157 (27.0) | 145 (26.0) | 157 (27.0) | 145 (26.0) |
| Europe | 312 (53.7) | 305 (54.7) | 312 (53.7) | 305 (54.7) |
| Asia | 105 (18.1) | 99 (17.7) | 105 (18.1) | 99 (17.7) |
| Mean body mass index, kg/m2 (SD) | 25.0 (3.50) | 24.9 (3.49) | 25.0 (3.62) | 24.9 (3.67) |
| Prevalent vertebral fracture at baseline, n (%) | 132 (22.8)a | 123 (22.0) | 140 (24.1) | 124 (22.3) |
| At least one priorb nonvertebral fracture, n (%) | 282 (48.5) | 272 (48.7) | 293 (50.4) | 277 (49.6) |
| Mean BMD T-score (SD) | ||||
| LS | −2.91 (0.82) | −2.88 (0.86) | −2.87 (0.867) | −2.11 (0.997) |
| TH | −1.91 (0.76) | −1.88 (0.72) | −1.93 (0.758) | −1.63 (0.742) |
| FN | −2.17 (0.68) | −2.15 (0.62) | −2.20 (0.695) | −1.95 (0.656) |
Some data in this table originally appeared in Cosman et al. (10).
a
Of 580 participants.
b
Based on fractures that occurred prior to ACTIVE baseline visit, excluding those of spine, breast bone, knee cap, toes, fingers, skull, and facial bones.