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Quantification performance of the four scanners with 500 ps TOF and 4-mm DOI detectors. All prompt events (true+scatters+randoms) are considered. CRC vs. variance curves of 2-mm ROI (a) and 10-mm ROI (c); Variance reduction factor of different scanners over the 4R reference scanner for 2-mm ROI (b) and 10-mm ROI (d).
