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. Author manuscript; available in PMC: 2019 May 18.
Published in final edited form as: Chembiochem. 2018 Apr 26;19(10):1031–1035. doi: 10.1002/cbic.201800121

Table 1.

Base and solvent screen for stapling of BCL-9 peptide (i, i+4) shown in Figure 2B. t=24 hrs, T=25°C.

Solvent Base (20 equiv.) Conversion[a] (%)
DMF DIEA 63
DMF DBU 28
DMSO DIEA 76
DMSO DBU 38
NMP DIEA 16
TFE DIEA 9
[a]

Percent conversion by HPLC peak area.