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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Cancer Res. 2018 Jun 5;78(16):4445–4451. doi: 10.1158/0008-5472.CAN-17-1123

Figure 2. Targeting Kras and Tp53 mutations to the SOX9+ compartment promotes BilIN and iCCA.

Figure 2

A. Cre-mediated recombination was induced in Sox9-CreERT2;KrasLSL-G12D;Tp53f/f mice via tamoxifen injections between ages 4-8 weeks, and mice were followed for signs of illness (n=9 mice). B. Kaplan-Meier analysis displaying time until illness of SOX9-KP mice. C. H&E and panCK IHC staining of liver sections revealing progressive spectrum of biliary lesions in the SOX9-KP model. Scale bars, 100μm. Insets show 3× magnification view.