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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Cancer Res. 2018 Jun 5;78(16):4445–4451. doi: 10.1158/0008-5472.CAN-17-1123

Figure 3. Hep-KP-derived iCCA exhibits activity in Notch signaling.

Figure 3

A. qPCR analyses for Notch ligands Jag1 and Dll1 and Notch target genes Hes1 and Hey1. B. Immunofluorescence (IF) for the Notch ligand JAG1 and the biliary marker KRT19 in DDC injured liver demonstrating expression in the CK-19+ biliary compartment and in iCCA in both SOX9 and Hep-KP models. Scale bars, 50μm. Insets show 3× magnification view.