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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Cancer Res. 2018 Jun 5;78(16):4445–4451. doi: 10.1158/0008-5472.CAN-17-1123

Figure 4. Tp53 restricts hepatocyte-to-cholangiocyte reprogramming.

Figure 4

A. Tp53f/f or Tp53+/+ mice with the Rosa26LSL-YFP reporter were injected with AAV8-TBG-Cre to induce hepatocyte-specific Cre-mediated recombination. After recovery, mice were put on a 2-week DDC diet to induce hepatocyte-to-cholangiocyte reprogramming. B. Quantification of YFP+/KRT19+ cells. Representative images are shown of YFP+/KRT19+ cells and adjacent YFP−/KRT19+ cells (n=4 mice/cohort, 15 portal fields/mouse p = 0.05 by unpaired t-test). Scale bars, 25μm. Insets show 3× magnification view.