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. 2018 Aug 17;13(8):e0202687. doi: 10.1371/journal.pone.0202687

Table 1. Ultrasonographic diagnoses, cytological diagnoses, and BRAF mutation analyses of 200 thyroid nodules according to final results.


BRAF mutation analysis
Negative (n = 119, 59.5%) Positive (n = 81, 40.5%)
US diagnosis
Benign
(n = 44, 22%)
NH (1), NSBN (41);
(n = 42, 21%)
NH (1), NSBN (1);
(n = 2, 1%)
Probably benign
(n = 38, 19%)
NH (2), FA (2), NSBN (33);
(n = 37, 18.5%)
PTC (1);
(n = 1, 0.5%)
Indeterminate
(n = 20, 10%)
PTC (1), FTC (1), FA (1), NSBN (9);
(n = 12, 6%)
PTC (8);
(n = 8, 4%)
Suspicious for malignancy
(n = 57, 28.5%)
PTC (10), MTC (1), NH (1),
NSBN (10);
(n = 22, 11%)
PTC (35);
(n = 35, 17.5%)
Malignant
(n = 41, 20.5%)
PTC (5), MTC (1);
(n = 6, 3%)
PTC (35);
(n = 35, 17.5%)
Cytological diagnosis
(Bethesda category)
I (n = 5, 2.5%) PTC (1), NSBN (3);
(n = 4, 2%)
PTC (1);
(n = 1, 0.5%)
II (n = 99, 49.5%) PTC (2), FTC (1), FA (3), NH (2), NSBN (84);
(n = 92, 46%)
PTC (5), NH (1), NSBN (1);
(n = 7, 3.5%)
III (n = 18, 9%) PTC (3), NSBN (6);
(n = 9, 4.5%)
PTC (9);
(n = 9, 4.5%)
IV (n = 0, 0%) 0 0
V (n = 25, 12.5%) PTC (3), NH (2);
(n = 5, 2.5%)
PTC (20);
(n = 20, 10%)
VI (n = 53, 26.5%) PTC (7), MTC (2);
(n = 9, 4.5%)
PTC (44);
(n = 44, 22%)

Note.—Numbers in parentheses are prevalence of each item. US, ultrasonography; NH, nodular hyperplasia; NSBN, Non-surgical benign nodules, which were finally determined by repeated fine-needle aspiration cytology or fine-needle aspiration cytology and follow-up ultrasonographic findings. FA, follicular adenoma; PTC, papillary thyroid carcinoma; FTC, follicular thyroid carcinoma; MTC, medullary thyroid carcinoma.