Table 1. Ultrasonographic diagnoses, cytological diagnoses, and BRAF mutation analyses of 200 thyroid nodules according to final results.
BRAF mutation analysis | ||
---|---|---|
Negative (n = 119, 59.5%) | Positive (n = 81, 40.5%) | |
US diagnosis | ||
Benign (n = 44, 22%) |
NH (1), NSBN (41); (n = 42, 21%) |
NH (1), NSBN (1); (n = 2, 1%) |
Probably benign (n = 38, 19%) |
NH (2), FA (2), NSBN (33); (n = 37, 18.5%) |
PTC (1); (n = 1, 0.5%) |
Indeterminate (n = 20, 10%) |
PTC (1), FTC (1), FA (1), NSBN (9); (n = 12, 6%) |
PTC (8); (n = 8, 4%) |
Suspicious for malignancy (n = 57, 28.5%) |
PTC (10), MTC (1), NH (1), NSBN (10); (n = 22, 11%) |
PTC (35); (n = 35, 17.5%) |
Malignant (n = 41, 20.5%) |
PTC (5), MTC (1); (n = 6, 3%) |
PTC (35); (n = 35, 17.5%) |
Cytological diagnosis (Bethesda category) |
||
I (n = 5, 2.5%) | PTC (1), NSBN (3); (n = 4, 2%) |
PTC (1); (n = 1, 0.5%) |
II (n = 99, 49.5%) | PTC (2), FTC (1), FA (3), NH (2), NSBN (84); (n = 92, 46%) |
PTC (5), NH (1), NSBN (1); (n = 7, 3.5%) |
III (n = 18, 9%) | PTC (3), NSBN (6); (n = 9, 4.5%) |
PTC (9); (n = 9, 4.5%) |
IV (n = 0, 0%) | 0 | 0 |
V (n = 25, 12.5%) | PTC (3), NH (2); (n = 5, 2.5%) |
PTC (20); (n = 20, 10%) |
VI (n = 53, 26.5%) | PTC (7), MTC (2); (n = 9, 4.5%) |
PTC (44); (n = 44, 22%) |
Note.—Numbers in parentheses are prevalence of each item. US, ultrasonography; NH, nodular hyperplasia; NSBN, Non-surgical benign nodules, which were finally determined by repeated fine-needle aspiration cytology or fine-needle aspiration cytology and follow-up ultrasonographic findings. FA, follicular adenoma; PTC, papillary thyroid carcinoma; FTC, follicular thyroid carcinoma; MTC, medullary thyroid carcinoma.