Fig. 4.

T cell subsets predict intolerance for higher lenalidomide doses. a Gating strategy to identify naïve and memory subsets and to measure PD-1 expression; b percentage of PD1-positive cells in CD4+ cells, CD 4 memory T cells and central and effector memory subgroups from pretreatment samples from 41 patients treated in the trial. Patients were categorised into two groups depending on whether they reached a composite endpoint of observed non-haematologic dose-limiting toxicities or inability to escalate dose beyond 5 mg lenalidomide