Table 1.

Patient characteristics

Baseline characteristics
Median age, years (range, IQR)	66 (43–79, 61–70)
Leucocytes, ×109 cells/L (range, IQR)	94.6 (11–374, 49.3–149)
Creatinine clearance, ml/min (median, range, IQR)	72.5 (32.5–141.7, 61.5–91.6)
Risk factors
Rai stage III/IV	22/44 (50%)
B symptoms	17/45 (38%)
FISH cytogenetic (highest risk)
Del(13q)	19/45 (42%)
Trisomy 12	7/45 (16%)
Del(11q)	10/45 (22%)
Del(17p)	3/45 (7%)
No cytogenetic abnormalities	6/45 (13%)
Gene mutations
ATM	20/42 (48%)
BIRC3	2/42 (5%)
NFKBIE	6/42 (14%)
NOTCH1	13/42 (31%)
SF3B1	4/42 (9%)
TP53	3/42 (7%)
ZNF292	7/42 (16%)
Unmutated IgVH	21/38 (55%)
β2 microglobulin ≥ 3.9 mg/L	28/44 (64%)