Table 2.

Distributions of ACE allele and genotypes in different studies’ susceptibility to COPD

Study	Language	Year	COPD					Control					HWE
			DD	ID	II	D	I	DD	ID	II	D	I
COPD
Ahsan et al10	English	2004	5	12	10	22	32	10	31	23	51	77	0.93
Ayada et al20	English	2014	13	26	8	52	42	28	28	8	84	44	0.81
Busquets et al11	English	2007	27	40	7	94	54	53	79	27	185	133	0.79
Gu et al22	Chinese	2003	57	37	28	151	93	25	85	49	135	183	0.24
Hopkinson et al13	English	2004	25	49	29	99	107	24	49	28	97	105	0.78
Jiang and Zhang24	Chinese	2002	24	20	16	68	52	5	10	15	20	40	0.17
Kuzubova et al18	English	2013	17	29	17	63	63	22	49	24	93	97	0.75
Mlak et al25	English	2016	60	99	47	219	199	51	73	41	175	155	0.15
Pabst et al7	English	2009	33	76	43	142	162	50	69	39	169	147	0.12
Simsek et al19	English	2013	31	20	15	82	50	13	19	8	45	35	0.83
Tkácová et al17	English	2005	20	31	15	71	61	31	68	19	130	106	0.07
Ulasli et al16	English	2013	47	17	16	111	49	33	10	6	76	22	0.003
Xu21	Chinese	2002	22	56	32	100	120	7	25	23	39	71	0.96
Yildiz et al15	English	2003	14	21	7	49	35	12	18	10	42	38	0.54
Zhang et al23	Chinese	2008	13	27	21	53	69	9	28	20	46	68	0.88

			COPD with PH						COPD without PH
PH
Jiang and Zhang24	Chinese	2002	13	8		9	34	26	11	12		7	34	26	NA
Ulasli et al16	English	2013	19	6		5	44	16	28	11		11	67	33	NA
Xu21	Chinese	2002	16	25		16	57	57	6	31		16	43	63	NA
Yildiz et al15	English	2003	7		17		NA	NA	4		10		NA	NA	NA

Abbreviations: ACE, angiotensin-converting enzyme; HWE, Hardy–Weinberg equilibrium; PH, pulmonary hypertension; NA, not available.