Table 2.
Characteristics of matched cases and controls.
| Characteristic | Cases | Controls | p-value |
|---|---|---|---|
| Number (N) | 101 | 198 | |
| NOS3, rs1799983, T allele freq | 55/198 = 0.28 | 96/382 = 0.25 | 0.556 |
| NOS3, rs3918227, A allele freq | 17/184 = 0.09 | 34/310 = 0.11 | 0.647 |
| GNB3, rs5442, A allele freq | 9/196 = 0.05 | 22/368 = 0.06 | 0.621 |
| DDAH1, rs10158674, C allele freq | 22/182 = 0.12 | 38/378 = 0.10 | 0.560 |
| DDAH1, rs233115, A allele freq | 61/202 = 0.30 | 117/392 = 0.30 | 0.995 |
| Age, mean years (SD) | 24.12 (6.52) | 24.01 (5.41) | 0.855 |
| Parity (N, % nulliparous) | 67 (66.2) | 80 (40.4) | <0.001† |
| Gestation at first prenatal visit mean weeks from LMP (SD) | 11.78 (7.00) | 13.48 (7.73) | 0.026 |
| Weight (lbs) at first prenatal | 180.9 (45.1) | 162.3 (38.1) | <0.001 |
| Body mass index (BMI) | 30.59 (6.97) | 27.65 (6.43) | <0.001 |
| Gestational diabetes, N (% yes) | 13 (12.9) | 12 (6.1) | 0.170 |
| Weeks of gestation at delivery | 36.91 (3.98) | 39.27 (1.96) | <0.001 |
| Birth weight of infant (grams) | 3041 (966.1) | 3452 (584.3) | <0.001 |
| Mother’s educational attainment (years of education) | 12.02 (1.81) | 12.29 (2.21) | 0.203 |
| Maternal smoking, N (% yes) | 38/95 (40.0 ) | 90/185 (48.6) | 0.193 |
| Maternal smoking (mean cigarettes smoked) | 3.39 (5.68) | 4.80 (6.81) | 0.034 |
| Mean systolic blood pressure (mmHg) | 162.3 (17.3) | 134.1 (16.0) | <0.001 |
| Mean diastolic blood pressure (mmHg) | 97.1 (10.1) | 79.0 (9.9) | <0.001 |
*
Differences between means evaluated with paired t test.
†
Differences between discrete variables evaluated with McNemar’s chi-square test.