Table 4.
Correlation between plasma pTau181 or total tau with tau PET entorhinal cortex SUVR by clinical diagnosis and elevated Aβ PET
| Clinical diagnosis and Aβ PET status* | Phospho-tau 181 | Total tau | ||
|---|---|---|---|---|
| Spearman’s rho | P value | Spearman’s rho | P value | |
| CU A− | −0.057 | 0.573 | 0.238 | 0.017 |
| CU A+ | 0.287 | 0.015 | 0.069 | 0.563 |
| MCI A− | 0.284 | 0.136 | 0.212 | 0.270 |
| MCI A+ | 0.437 | 0.020 | 0.104 | 0.598 |
| AD A+ | 0.125 | 0.456 | 0.159 | 0.341 |
| All A− | 0.018 | 0.835 | 0.228 | 0.009 |
| All A+ | 0.580 | <0.001 | 0.194 | 0.022 |
Abbreviations: AD, Alzheimer’s disease dementia; Aβ, amyloid-beta; CU, cognitively unimpaired; MCI, mild cognitive impairment; PET, positron emission tomography; SUVR, standardized uptake value ratio.
A+ = Aβ PET SUVR>1.42.