Figure 4. G551D-CFTR exhibits defective binding to trafficking and cytoskeletal components at the plasma membrane.

A. Scatter plot depicting the relative fold change in binding affinity between proteins recovered with G551D- and WT-CFTR. The recovered proteins were categorized based on their functional or subcellular site of action. The data is represented as the log10 of the fold change relative to WT (G551D:WT) and the black bars represent the median log10-FC value for each category. B. Minimal network depicting the connectivity between CDC42, RAC1, IQGAP1, GDI1 and ACTR3, involved in trafficking and cytoskeletal rearrangement.