Table 3.

Vx770 treatment restores the binding of Rac1, CDC42, IQGAP, GDI1 and ACTR to G551D-CFTR

Protein	RAC1	CDC42	IQGAP	GDI	ACTR3
Log2 FC (G551D vs WT)	−15.0	−1.2	−9.2	−6.9	−5.6
p-Value	0.004	0.009	0.004	0.01	0.01
Log2 FC (DMSO vs 770)	−12.4	−2.4	−11.0	−8.3	−2.3
p-Value	5,2×10−5	0.005	7.1×10−5	0.0002	0.0005