Skip to main content
. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Hepatology. 2018 May 21;68(2):496–514. doi: 10.1002/hep.29849

Fig. 6. Hepatic inhibition of mTORC1 protects against alcohol-induced hepatic inflammation, apoptosis, and liver injury in mice.

Fig. 6

A. Liver mRNA levels of pro-inflammatory regulators, neutrophil markers (Ly6G, MPO and CD11b), and macrophage marker (F4/80) were analyzed by real-time PCR. B. Hepatic activity of Akt, the major hepatocyte survival regulator, is upregulated by DEPTOR in chronic-binge ethanol-fed mice. C. Liver injury is assessed by measuring serum ALT levels. D. Overexpressing DEPTOR protects against alcohol-induced hepatocyte apoptosis, as evidenced by reduced caspase-3 cleavage. E. Rapamycin administration alleviates alcohol-mediated inhibition of Akt and induction of hepatic apoptosis and injury. F. Overexpression of DN-S6K1 ameliorates alcohol-induced hepatic apoptosis and liver damage. The data are presented as the mean ± SEM, n = 4–7. *P < 0.05, vs. pair-fed mice; #P < 0.05, vs. corresponding ethanol-fed mice.