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. Author manuscript; available in PMC: 2019 Sep 14.
Published in final edited form as: J Mol Biol. 2018 Jun 15;430(18 Pt A):2875–2899. doi: 10.1016/j.jmb.2018.06.016

Figure 2.

Figure 2

Schematic diagram of three concepts used for identification of cancer drivers. Nodes represent proteins while edges represent interactions between proteins. A) Identification of driver pathways, where the nodes within the shaded region belongs to the pathway. B) Identification of driver genes, where red nodes correspond to the proteins encoded by driver genes within the pathway (outlined). C) Identification of driver mutations targeting the driver genes. Sizes of the nodes represent mutation frequency. Pie charts on the nodes display the percentage of driver (red) and passenger (pink) mutations.