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. Author manuscript; available in PMC: 2018 Aug 18.
Published in final edited form as: ACS Chem Biol. 2018 Jun 12;13(8):2161–2169. doi: 10.1021/acschembio.8b00336

Table 1.

Antimicrobial agents.

Antimicrobial Agent Sequence Mass (Da) Net Charge MIC PM1
LL-37 LLGDFFRKSKEKIGKEFKRI-VQRIKDFLRNLVPRTES 4493 +6 4
Cecropin A KWKLFKKIEKVGQNIRDGII-KAGPAVAVVGQATQIAK-NH2 4404 +7 0.9
Melittin GIGAVLKVLTTGLPALISWI-KRKRQQ-NH2 2846 +6 5
β-peptide copolymer1 MM63:CHx37 graphic file with name nihms972749t1.jpg ~7000 63% cationic sidechains 25 μg/mL
CM15 KWKLFKKIGAVLKVL-NH2 1770 +6 5
1

Minimum inhibitory concentration (in μM) against WT MG1655 E. coli over 6-hr period in aerated EZRDM medium at 30°C, determined by OD for successive two-fold dilutions in 96 well plates. Copolymer MM63:CHx37 lacks a defined molar mass, so MIC is in μg/mL. The molecular weight of an “average” copolymer is ~7 kDa. Average is 35 subunits long, with 37% CHx (cyclohexyl) and 63% MM (mono-methyl) sidechains; see Ref. 13 for details. Thus an MIC of 25 μg/mL corresponds to a molar concentration of about 4 μM.