REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Beta-Actin HRP	Cell Signaling Technology	Product # 5125
Caspase-3 (Full Length) (Rabbit)	Cell Signaling Technology	Product # 9662
PARP-1 (Rabbit)	Cell Signaling Technology	Product # 9532
MEK1 (Rabbit)	Cell Signaling Technology	Product # 9146
MEK2 (Rabbit)	Cell Signaling Technology	Product # 9147
p-MEK1/2 (Ser217/Ser221) (Rabbit)	Cell Signaling Technology	Product # 9121
p-ERK1/2 (Thr202/Tyr204) (Rabbit)	Cell Signaling Technology	Product # 4370
Total ERK1/2 (Rabbit)	Cell Signaling Technology	Product # 4695
Annexin V-FITC	Southern Biotechnology	Cat # 10040-02
IgG (Rabbit) HRP	Cell Signaling Technology	Product # 7074
Chemicals, Peptides, and Recombinant Proteins
PAC-1	Putt, et al., 2006	N/A
Raptinal	Palchaudhuri, et al., 2015	N/A
Vemurafenib	LC Laboratories	Cat # V-2800
Gefitinib	Cayman Chemicals	Cat # 13166
Osimertinib	MedChem Express	Cat # HY-15772
Ceritinib	MedChem Express	Cat # HY-15656
Imatinib	MedChem Express	Cat # HY-15463
Trametinib	MedChem Express	Cat # HY-10999
BSA	Research Products International Corp.	Cat # A30075-100.0
Sulforhodamine B (SRB)	Sigma Aldrich	Cat # 230162
Acetic Acid	Fisher Scientific	Cat # A38-212
Propidium Iodide	Sigma Aldrich	Cat # 81845
Ac-DEVD-AFC	Cayman Chemicals	Cat # 14459
HEPES	Fisher Scientific	Cat # BP310-1
Sodium Chloride	Fisher Scientific	Cat # S271-500
DTT	Sigma Aldrich	DTT-RO ROCHE
EDTA	Fisher Scientific	Cat # S311-100
Triton-X-100	Fisher Scientific	Cat # BP151-100
Q-VD-OPh	Cayman Chemical	Cat # 15260
RIPA Buffer	Cold Spring Harbor Protocols	doi:10.1101/pbd.rec10617
Protease Inhibitor Cocktail III EDTA-Free	Calbiochem	Cat # 539134
Phosphatase Inhibitor Cocktail IV	BioVision	Cat # K282-1
SDS (Tris/Glycine) Buffer (10×)	BioRad	Cat # 161-0732
Sucrose	EMD Millipore	Cat # SX1075
Tris Base	Fisher Scientific	Cat # BP152-500
Calcium Chloride	Fisher Scientific	Cat # AC349610
Critical Commercial Assays
Pierce BCA Reagents A/B	Thermo Fisher Scientific	Cat # 23225
Experimental Models: Cell Lines
A375	ATCC	Cat # CRL-1619
K-562	ATCC	Cat # CCL-243
PC-9 GR	Prof. Eric Haura, Moffitt Cancer Center	N/A
H3122	Prof. Eric Haura, Moffitt Cancer Center	N/A
H1975	Prof. Eric Haura, Moffitt Cancer Center	N/A
SK-MEL-5	ATCC	Cat # HTB-70
Software and Algorithms
ANOVA 2 Way T Test	OriginPro V10	https://www.originlab.com/
FCS Express V5	De Novo software	https://www.denovosoftware.com/
Two Way T-Test	Microsoft Excel 16.12	https://products.office.com/en-us/home
Other
Mini-PROTEAN TGX Gels (4–20%)	BioRad	Cat # 456-1096
PDVF Membrane	Millipore	Cat # IPVH00010
Stripping Buffer	Thermo Fisher	Cat # 21059
SuperSignal West Pico	Thermo Fisher	Cat # 34577
BD LSR II Flow Cytometer	BD Biosciences	n/a
GelDoc XR	BioRad	Cat # 1708195
ChemiDoc Touch	BioRad	Cat # 17001401
SpectraMax M3	Molecular Devices	Cat # M3