. Author manuscript; available in PMC: 2019 Aug 1.

Published in final edited form as: Alzheimers Dement. 2018 Mar 28;14(8):1052–1062. doi: 10.1016/j.jalz.2018.02.015

Table 3.

Diagnostic and differential diagnostic values of CSF biomarkers in AD in the clinical cohort.

	α-syn^*	pS129/α-syn^*	Aβ₄₂^*	t-tau^*	p-tau^*	t-tau/Aβ₄₂^*	Combined model^**
AD vs HC
AUC	0.573	0.573	0.890	0.848	0.789	0.891	0.931^†
Sens%	58.8	71.9	86.8	77.2	78.9	90.4	92.1
Spec%	60.4	45.8	83.3	83.3	72.9	81.3	85.4
p-value	0.142	0.141	5.13E-15	3.03E-12	6.25E-9	4.56E-15	5.03E-18
AD vs FTD
AUC	0.760	0.767	0.860	0.831	0.857	0.873	0.893^‡
Sens%	51.8	58.8	79.8	73.7	68.4	76.3	80.7
Spec%	89.3	82.1	80.4	78.6	89.3	87.5	85.7
p-value	3.94E-8	1.55E-8	2.69E-14	2.35E-12	4.43E-14	4.94E-16	8.42E-17
AD vs LBD
AUC	0.751	0.746	0.854	0.849	0.768	0.886	0.900^†
Sens%	78.1	79.8	88.6	75.4	77.2	78.9	89.5
Spec%	64.3	64.3	73.8	79.5	70.7	89.7	82.1
p-value	1.57E-6	2.57E-6	1.27E-11	8.17E-11	3.59E-7	1.73E-13	9.50E-14
AD vs ALS
AUC	0.858	0.859	0.939	0.912	0.942	0.939	0.947^‡
Sens%	87.7	83.3	94.7	80.7	95.6	86.8	96.5
Spec%	68.6	71.4	85.7	88.6	88.6	88.6	88.6
p-value	1.61E-10	1.35E-10	4.65E-15	1.88E-13	2.72E-15	1.72E-15	1.32E-15
AD vs PSP
AUC	0.740	0.788	0.715	0.882	0.889	0.900	0.915^†
Sens%	70.2	78.1	76.3	67.5	81.6	90.4	80.7
Spec%	77.8	77.8	66.7	100.0	88.9	88.9	100.0
p-value	0.017	0.004	0.032	1.41E-4	1.04E-4	4.34E-5	3.51E-5

Logistic model contains the CSF marker, age and sex of participants;

^**

Logistic model contains CSF α-syn, Aβ₄₂, t-tau^† or p-tau^‡, age and sex of participants.