Table 3.
α-syn* | pS129/α-syn* | Aβ42* | t-tau* | p-tau* | t-tau/Aβ42* | Combined model** |
|
---|---|---|---|---|---|---|---|
AD vs HC | |||||||
AUC | 0.573 | 0.573 | 0.890 | 0.848 | 0.789 | 0.891 | 0.931† |
Sens% | 58.8 | 71.9 | 86.8 | 77.2 | 78.9 | 90.4 | 92.1 |
Spec% | 60.4 | 45.8 | 83.3 | 83.3 | 72.9 | 81.3 | 85.4 |
p-value | 0.142 | 0.141 | 5.13E-15 | 3.03E-12 | 6.25E-9 | 4.56E-15 | 5.03E-18 |
AD vs FTD | |||||||
AUC | 0.760 | 0.767 | 0.860 | 0.831 | 0.857 | 0.873 | 0.893‡ |
Sens% | 51.8 | 58.8 | 79.8 | 73.7 | 68.4 | 76.3 | 80.7 |
Spec% | 89.3 | 82.1 | 80.4 | 78.6 | 89.3 | 87.5 | 85.7 |
p-value | 3.94E-8 | 1.55E-8 | 2.69E-14 | 2.35E-12 | 4.43E-14 | 4.94E-16 | 8.42E-17 |
AD vs LBD | |||||||
AUC | 0.751 | 0.746 | 0.854 | 0.849 | 0.768 | 0.886 | 0.900† |
Sens% | 78.1 | 79.8 | 88.6 | 75.4 | 77.2 | 78.9 | 89.5 |
Spec% | 64.3 | 64.3 | 73.8 | 79.5 | 70.7 | 89.7 | 82.1 |
p-value | 1.57E-6 | 2.57E-6 | 1.27E-11 | 8.17E-11 | 3.59E-7 | 1.73E-13 | 9.50E-14 |
AD vs ALS | |||||||
AUC | 0.858 | 0.859 | 0.939 | 0.912 | 0.942 | 0.939 | 0.947‡ |
Sens% | 87.7 | 83.3 | 94.7 | 80.7 | 95.6 | 86.8 | 96.5 |
Spec% | 68.6 | 71.4 | 85.7 | 88.6 | 88.6 | 88.6 | 88.6 |
p-value | 1.61E-10 | 1.35E-10 | 4.65E-15 | 1.88E-13 | 2.72E-15 | 1.72E-15 | 1.32E-15 |
AD vs PSP | |||||||
AUC | 0.740 | 0.788 | 0.715 | 0.882 | 0.889 | 0.900 | 0.915† |
Sens% | 70.2 | 78.1 | 76.3 | 67.5 | 81.6 | 90.4 | 80.7 |
Spec% | 77.8 | 77.8 | 66.7 | 100.0 | 88.9 | 88.9 | 100.0 |
p-value | 0.017 | 0.004 | 0.032 | 1.41E-4 | 1.04E-4 | 4.34E-5 | 3.51E-5 |
Logistic model contains the CSF marker, age and sex of participants;
Logistic model contains CSF α-syn, Aβ42, t-tau† or p-tau‡, age and sex of participants.