Table 5.
Management and treatment outcomes of the patients who required vitamin K1 therapy
| Patients that required vitamin K1 therapy | p value* | ||
|---|---|---|---|
| Patients with exposure history (n = 31) | Patients without exposure history (n = 10) | ||
| Number of patients (n (%)) | 11 (35) | 10 (100) | 0.0015 |
| Adequate dose of vitamin K1 given (n (%)) | 11 (100) | 8 (80) | 0.4150 |
| Time to achieve adequate vitamin K1 dose, median (IQR) | 1.0 days (1.0–2.5 days) | 7.0 days (4.5–13.5 days) | 0.0128 |
| INR rebound after initiation of vitamin K1 (n (%)) | 0 (0) | 8 (80) | 0.0009** |
| Time to normalize INR, median (IQR) | |||
| INR > 1.5 and ≤ 2.5 | 3.0 days (2.0–3.0 days) | – | – |
| INR > 2.5 | 8.0 days (4.0–12.0 days) | 18.5 days (14.0–23.0 days) | 0.0299 |
*By Mann-Whitney U test unless otherwise specified
**By t test