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. 2018 Mar 27;43(10):2075–2082. doi: 10.1038/s41386-018-0049-1

Fig. 3.

Fig. 3

LTD of PFC and MDT synapses is differentially controlled by Group I mGlu receptor subtype. a Bath application of 10 µM MPEP does not impair LTD of PFC-NAcSh synapses. b Bath application of MPEP completely blocks induction of LTD at MDT-D1(+) NAcSh synapses. c Summary of experiments performed in the presence of 10 µM MPEP. Values shown as percent baseline. d Application of 50 µM LY367385 completely blocks induction of LTD at PFC-NAcSh synapses. e LY367385 did not impair LTD at MDT-D1(+) synapses. f Summary of experiments performed in the presence of 50 µM LY367385. Values shown as percent baseline. g, h 5 min bath application of the Group I mGlu agonist R,S-DHPG (100 µM) induces a robust LTD at both PFC and MDT-D1(+)synapses in the NAcSh. i Summary of DHPG experiments at PFC and MDT synapses. Values shown as percent baseline.