Skip to main content
. 2018 Mar 27;43(10):2075–2082. doi: 10.1038/s41386-018-0049-1

Fig. 5.

Fig. 5

Model of mGlu regulation of NAcSh PFC and MDT synapses. 10 Hz light-evoked Group I mGlu LTD is differentially expressed at PFC and MDT synapses, with cortical synapses recruiting mGlu1 while thalamic inputs onto D1(+) MSNs recruits mGlu5. LTD at all synapses likely occurs via a post-synaptic mechanism as indicated by absence of changes in 1/CV2. Prior cocaine exposure blocks the expression of LTD at thalamic—D1(+) synapses but does not impair mGlu1 LTD at PFC synapses.