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. 2018 Aug 17;8:12386. doi: 10.1038/s41598-018-30204-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clinical features of the proband and the ZIC3 gene mutation. (a) Chest radiograph showing dextrocardia in the patient. (b) CT scan indicating that the liver and spleen of the patient are reversed, while the stomach is located in the middle of the body. (c) The trio family of the proband, in which the mother is a carrier. (d) Sanger sequencing results show that the hemizygous ZIC3 mutation was found in the proband, while his father did not carry this mutation, but his mother was a heterozygous carrier. The gray background indicates the nucleotide change from G to T in the patient at position 890.