Figure 4.
Effect of AUS0004 (wild-type strains) and the deletion mutants in a mouse model of systemic infection. Groups of 10 BALB/c female mice were injected intravenously with approximately 1 × 108 cells of the indicated strains. Data are expressed as the log10 colony-forming units (CFUs)/g of bacteria recovered from kidney and liver homogenates seven days after the challenge. The log10 CFUs of both kidneys were combined and averaged. A value of 0 was assigned to the uninfected organs. Horizontal bars represent geometric means. Log10 counts were compared for statistical significance by two-way ANOVA. P values < 0.05 were considered significant. *<0.05, **<0.005, ***<0.001.