Table 3.
Modified atomoxetine parameters used in PBPK development for the CYP2D6*10/*10 genotype group and for CYP2D6 extensive and poor metabolisers.
| Parameter | Reference value | Input value | Reference/Comment |
|---|---|---|---|
| (A) CYP2D6*10/*10 | |||
| Metabolic rate of CYP2D6 | 5 μL/min/mg | Shen et al.26 | |
| Metabolic rate of CYP2C19 | 0.75 μL/min/mg | 0.75 μL/min/mg | Ring et al.3 |
| Plasma clearance | 0.17 L/hr/kg | Calculated by PK-Sim | |
| (B) CYP2D6 EM | |||
| Metabolic rate of CYP2D6 | 50 μL/min/mg | 50 μL/min/mg | Ring et al.3 |
| Metabolic rate of CYP2C19 | 0.75 μL/min/mg | 0.75 μL/min/mg | Ring et al.3 |
| Plasma clearance | 0.25 L/hr/kg | Calculated by PK-Sim | |
| (C) CYP2D6 PM | |||
| Metabolic rate of CYP2D6 | 0.1 μL/min/mg | 0.1 μL/min/mg | Ring et al.3 |
| Metabolic rate of CYP2C19 | 0.86 μL/min/mg | 0.86 μL/min/mg | Ring et al.3 |
| Plasma clearance | 0.030 L/h/kg | Calculated by PK-Sim | |