Fig. 2.

Effect of α2a adrenergic receptor knockdown in the amygdala following administration of the cholinesterase inhibitor physostigmine in tests of anxiolytic (light–dark box) and antidepressant efficacy (forced swim and tail suspension). Mice were injected i.p. with either with physostigmine (0.25 mg/kg) or saline, 60 min before testing. Time spent in the light side during the light–dark box (a). Time spent immobile in the tail suspension test (b) and forced swim test (c). N = 10–15 per group. ***p < 0.001. All data are expressed as mean ± SEM