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. 2018 Aug 17;8:12330. doi: 10.1038/s41598-018-29923-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Statistical und mechanistic model. (A) Bi-exponential model for the description of time course data, parameterized by the intercepts A, B, and the initial slope α and the secondary slope β. (B) Model setup of the mechanistic, single-cell based clonal competition model of CML pathogenesis and treatment. Leukemic cells are shown in blue, normal cells in grey. Both cell types change between a state of proliferative inactivity (A) and a proliferative state (Ω) before cells differentiate into peripheral blood. TKI activity is indicated by the cytotoxic effect and the prolonged quiescence of leukemic stem cell in state A. The five parameters modified for the simulation screen are identified by roman numerals (i)–(v).