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. 2018 Feb 14;43(10):2000–2008. doi: 10.1038/s41386-018-0010-3

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© American College of Neuropsychopharmacology 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Administration of exendin-4 directly into the VTA dose dependently attenuated cocaine priming-induced reinstatement of drug-seeking behavior. a Infusions of exendin-4 (0.05 µg) directly into the VTA prior to a cocaine priming injection reduced active lever responses during subsequent reinstatement test sessions (n = 8). The asterisk indicates a significant difference in responding between rats pretreated with 0.05 µg exendin-4 and vehicle (*p < 0.05, Bonferroni). Intra-VTA microinjection sites for the cocaine reinstatement study are shown in b. c Exendin-4 administration into the VTA had no effect on sucrose seeking (n = 7). Microinjection sites corresponding to intra-VTA infusions in sucrose reinstatement test sessions are shown in d.