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. 2018 Aug 17;8:12355. doi: 10.1038/s41598-018-30958-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Orientation selectivity is lower in cells expressing CR. (A) Two-photon image showing the most orientation-selective CR− cell (green), an averagely tuned CR− neuron (blue) and an untuned CR+ neuron (red). On the right, average responses and polar plots for the same cells. Colors represent stimulus directions. Grey indicates stimulus period. (B) Distribution of OSI for CR+ and CR− neurons. Red and green outlined dots are the examples shown in A. Vertical bars show mean. **Indicates p < 0.01. (C) Percentage of CR+ and CR− neurons with an OSI higher than 0.33. *Indicates p < 0.05. (D) Distribution of DSI is similar for CR+ and CR− neurons. Vertical bars show mean.