Fig. 1.

Cold Pressor Task pain threshold (top panels) and tolerance (bottom panels) as calculated by percent baseline latency (seconds) to report pain and withdraw the hand from cold water. Data are presented as mean values +/- SEM according to cannabis strength, oxycodone dose (2.5 mg, left panels; 5.0 mg, right panels), and time. Placebo oxycodone + inactive cannabis condition = PBO; placebo oxycodone + active cannabis condition = CAN; 2.5 mg oxycodone + inactive cannabis condition = 2.5 Oxy; 2.5 mg oxycodone + active cannabis condition = 2.5 O + C; 5.0 mg oxycodone + inactive cannabis condition = 5.0 Oxy; 5.0 mg oxycodone + active cannabis condition = 5.0 O + C. Baseline response is shown as BSL on the x-axis; response after oxycodone is indicated by C on the x-axis. Significant differences from placebo are indicated by *p ≤ 0.05 and **p ≤ 0.01; significant differences from active cannabis alone are indicated with ^#p ≤ 0.05