Table 4.
Abuse-liability ratings of oxycodone
Drug condition | Oxycodone | 0.0 mg | 0.0 mg | 2.5 mg | 2.5 mg | 5.0 mg | 5.0 mg |
Cannabis | 0.0% | 5.6% | 0.0% | 5.6% | 0.0% | 5.6% | |
Subjective effect | Strength | 10.1 ± 1.5 | 16.5 ± 1.9 | 12.6 ± 1.8 | 27.2 ± 2.4**, # | 16.18 ± 1.9 | 20.5 ± 2.1 |
Good drug | 10.8 ± 1.6 | 11.7 ± 1.7 | 11.1 ± 1.8 | 31.1 ± 2.9***, ## | 11.7 ± 1.7 | 22.6 ± 2.5* | |
Liking | 11.1 ± 1.7 | 16.7 ± 1.9 | 17.9 ± 2.0 | 39.0 ± 2.7***, # | 18.4 ± 2.1 | 20.6 ± 2.3 | |
Take again | 6.9 ± 1.3 | 12.1 ± 1.7 | 12.9 ± 2.0 | 39.3 ± 2.8***, ## | 15.9 ± 2.1 | 18.7 ± 2.3* |
Mean subjective ratings ± standard error of the mean (SEM) for the Capsule Rating Form under placebo conditions (inactive cannabis + 0 mg oxycodone), and oxycodone (2.5 and 5.0 mg) and active cannabis administered alone or together. Significant differences from placebo are indicated by **, p ≤ 0.01, and ***, p ≤ 0.001; significant differences from active cannabis alone are indicated with #, p ≤ 0.05, ##, p ≤ 0.01, and ###, p ≤ 0.001.