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. 2018 Feb 5;43(10):2046–2055. doi: 10.1038/s41386-018-0011-2

Table 4.

Abuse-liability ratings of oxycodone

Drug condition Oxycodone 0.0 mg 0.0 mg 2.5 mg 2.5 mg 5.0 mg 5.0 mg
Cannabis 0.0% 5.6% 0.0% 5.6% 0.0% 5.6%
Subjective effect Strength 10.1 ± 1.5 16.5 ± 1.9 12.6 ± 1.8 27.2 ± 2.4**, # 16.18 ± 1.9 20.5 ± 2.1
Good drug 10.8 ± 1.6 11.7 ± 1.7 11.1 ± 1.8 31.1 ± 2.9***, ## 11.7 ± 1.7 22.6 ± 2.5*
Liking 11.1 ± 1.7 16.7 ± 1.9 17.9 ± 2.0 39.0 ± 2.7***, # 18.4 ± 2.1 20.6 ± 2.3
Take again 6.9 ± 1.3 12.1 ± 1.7 12.9 ± 2.0 39.3 ± 2.8***, ## 15.9 ± 2.1 18.7 ± 2.3*

Mean subjective ratings ± standard error of the mean (SEM) for the Capsule Rating Form under placebo conditions (inactive cannabis + 0 mg oxycodone), and oxycodone (2.5 and 5.0 mg) and active cannabis administered alone or together. Significant differences from placebo are indicated by **, p≤ 0.01, and ***, p≤ 0.001; significant differences from active cannabis alone are indicated with #, p≤ 0.05, ##, p≤ 0.01, and ###, p≤ 0.001.