Table 4.
Longitudinal analysis of differentially remodeled genes
| ProbeID | Chr | Pos | Persistent allergics (n = 49) | Transient allergics (n = 115) | Gene | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Deltabeta (FU-BL) | Adj.P value deltabeta |
Log FC (FU-BL) | Adj. P value log FC |
Deltabeta (FU-BL) | Adj. P value deltabeta |
Log FC (FU-BL) | Adj. P. val log FC |
||||
| cg20995327 | Chr12 | 12,595,583 | 0.172 | 0.000 | −0.248 | 0.178 | 0.025 | 0.051 | 0.145 | 0.296 | LOH12CR 1 |
| cg22152180 | Chr2 | 238,904,315 | 0.079 | 0.000 | 0.134 | 0.536 | 0.026 | 0.095 | 0.125 | 0.296 | UBE2F |
| cg09775648 | Chr3 | 111,314,102 | 0.115 | 0.000 | −0.179 | 0.611 | 0.058 | 0.095 | −0.425 | 0.001 | ZBED2 |
| cg26319797 | Chr2 | 190,309,186 | 0.148 | 0.000 | −0.529 | 0.012 | 0.030 | 0.095 | −0.114 | 0.467 | WDR75 |
| cg24278087 | Chr11 | 44,597,119 | 0.072 | 0.000 | −0.196 | 0.428 | 0.014 | 0.101 | −0.088 | 0.591 | CD82 |
| cg05175803 | Chr17 | 78,765,948 | 0.136 | 0.000 | −0.230 | 0.323 | 0.025 | 0.141 | −0.154 | 0.390 | RPTOR |
| cg27403618 | Chr1 | 209,907,350 | 0.078 | 0.000 | −0.549 | 0.428 | 0.027 | 0.160 | −0.213 | 0.627 | HSD11B1 |
| cg12592365 | Chr16 | 15,583,606 | 0.100 | 0.000 | −0.408 | 0.345 | 0.042 | 0.160 | −0.075 | 0.612 | C16orf45 |
| cg02660643 | Chr2 | 69,735,185 | 0.097 | 0.000 | 0.023 | 0.931 | 0.016 | 0.160 | −0.033 | 0.758 | AAK1 |
| cg14174367 | Chr17 | 17,599,543 | 0.085 | 0.001 | −0.189 | 0.428 | 0.027 | 0.197 | −0.289 | 0.001 | RAI1 |
| cg25279613 | Chr8 | 145,022,842 | 0.056 | 0.001 | 0.245 | 0.498 | 0.029 | 0.197 | −0.104 | 0.467 | PLEC |
| cg17355385 | Chr2 | 158,712,427 | 0.068 | 0.001 | 0.030 | 0.931 | −0.022 | 0.245 | −0.089 | 0.758 | ACVR1 |
| cg20930706 | Chr1 | 172,558,180 | 0.055 | 0.001 | 0.141 | 0.428 | 0.026 | 0.455 | −0.071 | 0.607 | SUCO |
| cg15928524 | Chr3 | 111,314,186 | 0.055 | 0.001 | −0.179 | 0.611 | 0.016 | 0.464 | −0.162 | 0.296 | ZBED2 |
| cg00545580 | Chr6 | 154,560,711 | 0.092 | 0.002 | 0.695 | 0.012 | 0.014 | 0.556 | −0.075 | 0.612 | IPCEF1 |
| cg22992505 | Chr20 | 62,368,837 | −0.073 | 0.003 | −0.059 | 0.931 | 0.011 | 0.568 | −0.034 | 0.758 | LIME1 |
| cg03116016 | Chr7 | 24,956,523 | 0.079 | 0.004 | 0.000 | 0.998 | 0.007 | 0.805 | 0.046 | 0.774 | OSBPL3 |
| cg24323726 | Chr11 | 65,904,369 | 0.024 | 0.009 | −0.181 | 0.428 | −0.006 | 0.805 | 0.089 | 0.758 | PACS1 |
| cg04599190 | Chr17 | 78,571,214 | 0.061 | 0.018 | −0.230 | 0.323 | 0.002 | 0.805 | −0.039 | 0.758 | RPTOR |
| cg00957665 | Chr14 | 99,684,844 | 0.029 | 0.019 | 0.049 | 0.850 | 0.005 | 0.805 | −0.228 | 0.027 | BCL11B |
| cg25867265 | Chr2 | 145,182,344 | 0.034 | 0.023 | −0.228 | 0.536 | −0.005 | 0.805 | 0.295 | 0.106 | ZEB2 |
| cg11903019 | Chr1 | 202,128,508 | 0.051 | 0.025 | −0.428 | 0.006 | −0.009 | 0.805 | 0.349 | 0.053 | PTPN7 |
| cg16001422 | Chr16 | 87,491,587 | 0.026 | 0.029 | 0.255 | 0.323 | 0.004 | 0.876 | −0.102 | 0.719 | ZCCHC1 4 |
| cg21410897 | Chr10 | 104,406,345 | 0.033 | 0.040 | −0.323 | 0.049 | 0.003 | 0.876 | 0.124 | 0.390 | TRIM8 |
| cg10502206 | Chr5 | 66,306,763 | 0.007 | 0.384 | −0.168 | 0.464 | 0.002 | 0.896 | −0.081 | 0.758 | MAST4 |
| cg25298754 | Chr1 | 66,737,176 | 0.015 | 0.469 | 0.624 | 0.018 | −0.001 | 0.999 | 0.089 | 0.758 | PDE4B |
Change in DNA methylation (deltabeta) and gene expression (log FC) from baseline to follow-up are shown
BL: baseline; FU: follow-up